Crescentic glomerulonephritis with anti-GBM antibody but no glomerular deposition
نویسندگان
چکیده
منابع مشابه
Anti-GBM-associated crescentic glomerulonephritis with discrete IgG deposition, but with no electron-dense material in glomeruli.
Crescentic glomerulonephritis is characterized by extracapillary proliferation resulting from severe inflammatory injury of various aetiologies. It is usually rapidly progressive. Meanwhile, anti-glomerular basement membrane (GBM) antibody-mediated glomerular lesions induce crescentic glomerulonephritis. When associated with pulmonary haemorrhage, it is given the eponym 'Goodpasture's syndrome'...
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We are presenting a case of renal failure with anti-GBM and p-ANCA antibodies positive. Patients with dual antibodies are considered to be a vasculitis-variant of anti-GBM antibody nephritis. These patients may have atypical presentation and it may delay diagnosis and treatment. Recurrence rate is higher in these patients. We reviewed the literature of cases and studies on cresenteric glomerulo...
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We report a case of a 71-year-old man with rapidly progressive nephritic syndrome and dual positivity for anti-glomerular basement membrane antibody and myeloperoxidase-specific anti-neutrophil cytoplasmic antibody. Renal biopsy revealed crescentic, mainly cellular, glomerulonephritis with granulomatous lesions, and advanced membranous changes. Membranous nephropathy had apparently existed for ...
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Antiglomerular basement membrane (anti-GBM) antibodies are more often accompanied by myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA) than by proteinase 3 antineutrophil cytoplasmic antibody (PR3-ANCA). Both disease processes can affect the kidneys and/or the lungs. Patients with dual positive disease may have an atypical presentation which may delay diagnosis and treatment. Here ...
متن کاملAnti-GBM crescentic glomerulonephritis with intensive multinucleated giant cells: a case report
Anti-glomerular basement membrane (anti-GBM) disease is a rare but potentially lethal autoimmune disorder with progressive renal dysfunction in a short time span, which is accompanied with or without pulmonary hemorrhage. Serologic test shows positive anti-GBM antibodies, and extensive crescent formation in the renal biopsy, usually without multinucleated giant cells. Our study presents a case ...
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ژورنال
عنوان ژورنال: BMC Nephrology
سال: 2018
ISSN: 1471-2369
DOI: 10.1186/s12882-018-1027-x